The Pharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation represents an international collaborative effort led by the ECMO Pharmacology Network (ECMOPharmNet) to define global research priorities in ECMO pharmacology. Using the Delphi consensus method, multidisciplinary experts from more than 20 countries identified key gaps in our understanding of drug behavior during ECMO—spanning sedatives, analgesics, antimicrobials, anticoagulants, and and emerging therapeutics.

This position article serves as a roadmap for future investigations that aim to optimize medication use, advance pharmacokinetic and pharmacodynamic modelling, and ultimately improve outcomes for critically ill patients supported with ECMO.